One study suggests that Pycnogenol has no effect when given just 3 weeks beforehand, as it possibly requires a lag time to stabilize the immune response [17]. Symptoms of menopausal syndrome, also known as climacteric syndrome, include: hot flashes; chills; headache; and depression. Chemistry. PQQ (pyrroloquinoline quinone), also called methoxatin, is a vitamin-like compound that exists naturally in soil and a variety of foods, including spinach, kiwi, soybeans, and human breastmilk . (11, 12), While both eliminate pain, the pine bark extract is a far better choice. Pycnogenol treatment reduced the need for painkillers by 58% versus one percent in the placebo-treated group. 8 Proven Benefits of Pine Bark Extract - Healthy Focus Importantly, all studies found that Pycnogenol has to be taken at least 5 weeks before the allergy season in order to see potential benefits, with the best results in those who take it 7-8 weeks ahead. Traditionally, people might drink a brew made from pine bark -- rich in pycnogenol -- as a treatment. Here are some basic guidelines as reported by WebMD: While most studies do not indicate major side effects, pine bark extract may cause irritability and fatigue, and could interact with other drugs. 7. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. Erythritol: Is This Healthy Sweetener the Real Deal? Pycnogenol led to a reduction of muscle cramps from 4.8 a week to 1.3 at week four. Chanca Piedra: Benefits, Dosage, Side Effects, and More - Healthline A randomized, double-blind, placebo-controlled study of 60 patients aged six to 18 years old, was conducted over three months during which patients were randomly assigned to receive either Pycnogenol or placebo. Pycnogenol may have benefits for heart and artery health. (2006). Organika Pycnogenol 50mg 50 Tablets . Pycnogenol (150 mg/day) reduced pain in a study of 100 people with osteoarthritis after 3 months. Forty patients were treated with either 600 mg chestnut seed extract a day or 360 mg Pycnogenol a day over a period of four weeks. People who use the supplement along with their traditional medication usually take smaller doses than those who only take the supplement. Pycnogenol Benefits - Dr Sarah Brewer Vinpocetine is used to increase brain circulation, alertness, cognitive function, concentration, and memory, as well as to lower inflammation and oxidative stress.This article will explore vinpocetine's history, how it works, its potential benefits, and any possible safety issues . Asthma is caused by inflammation in the lungs, which makes it hard to breathe. In oneparticular study published in Research in Pharmaceutical Sciences, researchers investigated the antibacterial activity of pine bark extract essential oil on staph infections, E. coli and pseudomonas infections. For mild high blood pressure: 200 milligrams daily. It decreased concussion symptoms in 42 student-athletes with a history of sports-related concussions after 6 weeks. Pine bark extract contains active ingredients that can also be found in peanut skin, grape seed, and witch hazel bark. Its best to check with your doctor about the dosage, based on the symptoms you have and other possible conditions, prior to taking either pine bark extract or Pycnogenol. A 2017 review reported on the many benefits of using pine bark extract to reduce the effects of aging on skin. In a small/preliminary study of kids with asthma, pycnogenol helped improve symptoms. Additionally, athletes have endured less cramping and muscle pain when using the extract. Almost 400 years later, Dr. Jacques Masquelier from France came across Cartiers account and started to look for the active ingredients from the bark of the tree. (2012). Mental function. Sort By. It also may help those on blood pressure medications to reduce their dose [32]. Last medically reviewed on January 24, 2018. chronic anal fissure may take more than 6 weeks to heal. In this study, 155 peri-menopausal women were enrolled in a double-blind, placebo-controlled study. from the bark of the French maritime pine tree. This nerve affects our balance and hearing by sending signals to the brain. Pycnogenol has not been found to cause these issues however, it may take a little longer the feel the relief from pain than aspirin. New research shows . The Best Supplements for Healthy Digestion, How to Get the Protective Power of Vitamin K. 6 Vinpocetine Benefits + How It Works & Side Effects . Pycnogenol can help control blood pressure, which helps improve overall heart health. Dr. Steven Lamm did a great job at explaining the new benefits of pycnogenol. A trial of 132 people found that Pycnogenol (150 mg/day) may improve risk factors of metabolic syndrome including lowering triglyceride levels, blood pressure, and fasting glucose, decreasing waist circumference, and increasing HDL cholesterol levels [29]. Pycnogenol (125 mg/day) had the same effects in another study of 48 people with diabetes and high blood pressure. This bark extract has been around for about 450 years. He later extracted proanthocyanidins from the European coastal pine tree, which he named Pycnogenol.. Pycnogenol treatment led to significantly better improvement in the lung function and asthma symptoms. We believe that the most accurate information is found directly in the scientific source. Enzogenol, a slightly different pine bark extract, may help improve brain function after mild concussions. We take a look at what the science actually says. According to the lab results of 10 volunteers, a higher Pycnogenol dose (300 mg) may impact these enzymes after just 30 minutes [52]. Gotu Kola: Health Benefits, Side Effects, Uses, and More - WebMD The . Purity and potency of Pycnogenolare continuously monitored . In a good-quality study, 77 patients with osteoarthritis were treated with 100 mg of Pycnogenol daily and 79 patients were treated with placebo for three months. The effects of the pine bark extract showed significant lower levels of blood glucose and improved endothelial function when compared to placebo, concluding that supplementation of Pycnogenol for treating conventional diabetes may be beneficial. In a study of 100 healthy women mostly in their early 40s with mild sexual dysfunction, a combination product with Pycnogenol (Lady Prelox) improved sexual function over 8 weeks [74]. A study with four groups of 30 patients each were studied: (1) systemic Pycnogenol and local application; (2) local Pycnogenol only; (3) oral Pycnogenol and (4) medications only (control). Folic Acid Benefits, Deficiency, Foods, Side Effects, More - Dr. Axe They were given Pycnogenolfor a period of 10 days. In mice, luteolin prevented inflammation and allergic response in the lungs and nose by inhibiting inflammatory cytokines: IL-4, IL-5, and IL-1 3 []. Low-dose Pycnogenol (30 mg/day) may reduce pain in pregnant women, particularly hip, joint, lower back, groin, and calf cramps in the third trimester [71]. Helps Increase Athletic Performance. ", Panminerva Medica: "Supplementation with Pycnogenol improves signs and symptoms of menopausal transition.". It comes from the bark of a European pine tree. For that reason, you should be careful taking pine bark if you have hypertension or diabetes. Pycnogenol French maritime pine bark extract acts as a potent blend of antioxidants, it is a natural anti-inflammatory, stimulates generation of collagen and hyaluronic acid and help with natural dilation of blood vessels by supporting production of nitric oxide. This condition is due to the pooling of blood in the veins of the lower legs. 7. Add to Cart. This includes supporting healthy blood circulation, acting as a natural anti-inflammatory, helping to generate collagen and hyaluronic acid for improved skin health and aiding in the production of endothelial nitric oxide which helps to dilate blood . Diindolylmethane, or DIM for short, is a plant indolea plant compound with health-promoting properties. Upset stomach. Pine bark extract can make a great addition to your nutritional arsenal for its potent antioxidant support, as well as its added support for blood flow, blood sugar, inflammation, immunity, brain function and skin support. But what makes this miracle ingredient so amazing? She is a strong advocate of integrating scientific knowledge and holistic medicine. New research has shown promising results for those dealing with erectile dysfunction (ED) and diabetes. More research is needed to see how this supplement affects all of these conditions. Dr. Drew explains the benefits of probiotics for the gut microbiome and talks about the rise of leaky gut, and Dr. Steve shares how emotional stress can have real physical effects on the heart. but is for informational and educational purposes alone. Quality and active ingredients in supplements may vary widely from maker to maker. The goal of one study was to evaluate whether or not Pycnogenol could prevent edema (fluid build-up) during long-haul flights in healthy people. In combination with Mirtoselect, Pycnogenol may improve blood flow to the eye and reduce eye blood pressure as shown in a trial of 38 people [81]. The 2012 study on the anti-aging benefits of Pycnogenol is commonly-cited by anti-aging supplement manufacturers. In a third study, 19 men with fertility problems were given 200 mg Pycnogenol daily for 90 days. Pycnogenol is thought to be an antioxidant that helps protect cells from damage. Researchers suggest that it may have stronger benefits than elastic compression stockings. Lutein Benefits, Uses, Foods, Side Effects and More - Dr. Axe According to a study of 11 patients with lupus, pycnogenol may reduce symptoms, inflammation, and oxidative stress [54]. Although these may still be high quality, the active compounds are more likely to vary. The usual recommended duration of treatment for topical application is 7 days for Pycnogenol cream and 6 weeks for Pycnogenol powder. L-arginine is more effective when paired with L-citrulline or pycnogenol to combat erectile dysfunction and improve exercise performance. For asthma in children: 1 milligram per pound of body weight given in two divided doses. Pycnogenol French maritime pine bark extract's 4 basic properties. In a good-quality study, 100 patients with osteoarthritis of the knee were treated for three months either with 150 mg of Pycnogenol a day or placebo. 8 Proven Benefits of L-arginine - Nutrition and Fitness Central However, its always a good idea to start with a low dose so you can monitor how your body responds. Normalization of cardiovascular risk factors in peri-menopausal women with Pycnogenol [Abstract]. Grape Seed Extract: Benefits, Side Effects, Dosage, and Interactions The study provided clear evidence that Pycnogenol does, indeed, offer photoprotection however, it came out even better than expected, showing that it may be used to reduce hyperpigmentation of human skin while improving the skin barrier function and extracellular matrix homeostasis. (6). Blood clots form as a result of platelet aggregation, which is the platelets in the blood clumping together. A sitz bath, which involves sitting in warm water for 10 minutes, twice daily, is helpful to patients with anal itching, aching or burning and is known as one of the best ways to get rid of hemorrhoids fast. Video: Why You Need Zinc and Where to Find It. It also may increase the activity of genes that make collagen and hyaluronic acid in the body [64]. Some of the top lutein-rich foods to include in your diet are dark leafy greens like spinach and kale, broccoli . While the aspirin reduced the risk for cardiovascular disease and colorectal cancer, among other cancers, the risk of gastrointestinal bleeding outweighed those benefits, creating more risks to the body. All of our content is written by scientists and people with a strong science background. Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. Pycnogenol is known under different names in some countries, such as Oligopin, and Flavangenol in Japan [4, 5]. One way to add some extra flavor and nutrients to your day is by adding prune juice to your diet. Studies were conducted in Turkey on subjects who underwent abdominal surgery to determine if the pine bark extract could help reduce the inflammation. Erectile dysfunction has increased over the past decade or two, creating a pathway for various medications to land on the shelves of numerous medicine cabinets. 2. But a month after pycnogenol was stopped, the symptoms came back, suggesting that it may need to be used regularly to achieve the benefits [41]. Pycnogenol helps erectile dysfunction and diabetes through circulatory link Studies on human subjects have reported few side effects - even . Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. Pycnogenol improved symptoms, circulation, and reduced complications in 156 people with deep vein thrombosis (blot clots in deep leg veins) in a 12-month study. DOI: Marini A, et al. A small 2012 study on postmenopausal women found that pine bark extract improved hydration and elasticity of skin. Blood pressure is an important measure of how much blood is pumping from your heart to the rest of your body . Pycnogenol has four main components that contribute to its benefits for men's health. 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Another 2006 study examined the effects of the antioxidant activity of pine bark extract on oxidative stress, which is thought to be one of the nongenetic factors contributing to ADHD. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Some people who have asthma have higher levels of leukotrienes in their blood. One study involved a four-week treatment period followed by one week of no treatment or observation period. Pycnogenol effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women [Abstract]. after four weeks of treatment, Pycnogenol-treated patients showed definite evidence of improved in small blood vessel functions and circulation as compared to those not treated. 4 Items . Whole Foods Organic Allergy Medicine-drug Chewing gum with Pycnogenol (2.5 mg/piece) for 4 weeks reduced bad breath and mouth bacteria in a trial of 22 people [57]. In a study of 77 people with symptoms of Irritable Bowel Syndrome (IBS), Pycnogenol (150 mg/day) improved symptoms and reduced the frequency of attacks [77]. Ac., CYT, 12 Benefits of Ginkgo Biloba (Plus Side Effects & Dosage), Tongkat Ali (Eurycoma longifolia): Everything You Need to Know, reduce blood sugar levels in people with diabetes, are within two weeks of a scheduled surgery, medications, herbs, and supplements that affect the blood or clotting. are clickable links to these studies. Studies have found that supplementing with pycnogenol effectively strengthens the blood vessels, stabilizing blood pressure. Pycnogenol in metabolic syndrome and related disorders [Abstract]. Circulation and Jet Lag on Long Flights. A study of 147 people found that pycnogenol (100 mg/day) may improve running, push-ups, and sit-ups endurance in recreational athletes over an 8-week training program. If you take any medications regularly, talk to your doctor before you start using pycnogenol supplements. This article reviews tongkat ali, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Another study in 2012 showed that Pycnogenol alone, at a dose of 75 mg/day, increased skin hydration by 8% after just 6 weeks; in women with dry skin at baseline the increase was 21%. Grapes: Health Benefits, Nutrition, Recipes and Risks - Dr. Axe Here are the many health benefits believed to be possible with Pycnogenol: Now lets dive into the first condition it could help treat. Symptoms include swelling in ankles and legs, discolored skin and, if the skin is broken, the development of leg ulcers. Pine bark extract provides many benefits to the skin, including reducing the signs of aging. With time, the participants were able to handle more UV radiation without experiencing skin damage [63]. 4. Blood pressure is an important measure of how much blood is pumping from your heart to the rest of your body. COPD. However, a study of 24 adults with ADHD found that pycnogenol did not improve ADHD symptoms better than placebo. Improve cardiovascular health. As a skin cream, its safe to use for about seven days. If youre native to Oregon, you likely know all about marionberries. 3. Boost gastrointestinal health. Andrographis is a medicinal herb used to treat many health conditions, such as the common cold, osteoarthritis, and ulcerative colitis. In 1535, a French explorer by the name of Jacques Cartier found himself ice-bound on the St. Lawrence River. What Is Pycnogenol, and What's It Used For? - Wonder Labs Perimenopausal women who took pine bark extract for eight weeks noticed decreased cholesterol and triglyceride levels. A study of 68 people found that Pycnogenol, started 2 days prior to flying, may reduce the duration of jet lag symptoms [83]. During week, five without, treatment, reduction of cramps was maintained in all three groups. A study of 58 people with high blood pressure suggests that even lower doses (100 mg/day) may improve blood vessel health and reduce markers of high blood pressure (endothelin-1) after 12 weeks. It also provides powerful antioxidant protection and helps inhibit inflammatory factors to support. Pine bark extract has been studied regarding its relationship to exercise performance, oxidative stress and inflammation to body that has been imposed by exercise. 10 Ways to Control Blood Sugar without Medication, Pycnogenol (French Maritime Pine Bark Extract): 12 Benefits According to Studies, Reduces leaky blood vessels by making the wall proteins (collagen, elastin) more resistant to damage, Helps maintain high vitamin C and E blood levels for their antioxidant effects, Inhibits platelet aggregation like low-dose aspirin, Reduces hardening in the arteries by increasing nitric oxide production in blood vessels, leading to greater dilatation, Counteracts the damaging effects of ultraviolet radiation, Stimulates the immune system by boosting T and B cell functions, Protects brain cells from toxic chemicals. This condition can be temporary or permanent however, some studies have indicated that pine bark extract may help alleviate these symptoms due to its high presence of antioxidants. Enzogenol, a slightly different pine bark extract, improved cognitive function in a clinical trial of 42 older men after 5 weeks of supplementation [23]. Lets begin with asthma. In 1534, a French ship led by the famous explorer Jacques Cartier became stranded in ice near Quebec, Canada. Various studies, referenced at uofmhealth.org, have shown that a daily dosage of Pycnogenol . There are also several other natural ADHD remedies you can try. Results showed that one month of Pycnogenol led to a significant reduction of hyperactivity with improvement in attention and visual-motor coordination and concentration, as compared to no positive effects in the placebo group. Add to Cart. Pine Bark Extract Health Benefits, Nutrition and How to Use - Dr. Axe Pycnogenol: Health Benefits, Uses, Doses, Safety Information - WebMD Today, I want to share with you my secrets to reduce sugar Top 7 Benefits of Green Tea: The No. Top 10 Health Benefits of Nattokinase - Earth Clinic Considering that about 1 of 3 adults in the U . Moreover, Pycnogenol lowered the chemical, leukotrienes responsible for asthma attacks. 1 Anti-Aging Beverage, An surprisingstudy found that pine bark extract was far better than aspirin at inhibiting smoking-induced clotting, using lower amounts without the bleeding often found when using aspirin. Pycnogenol significantly improved the heavy feeling as well as the swelling. Rare cases of liver disease. Can Pycnogenol help? Animal studies have found that gotu kola makes it harder . Therefore, those who have autoimmune conditions could see their symptoms increase after taking it., Since Pycnogenol is used for so many conditions, doses can vary. For allergies: 50 milligrams twice daily. A number of clinical trials suggest that Pycnogenol may lower blood glucose if taken daily for at least 12 weeks. The crew fell extremely ill from scurvy, an extreme lack of vitamin C. Cartiers crew crossed paths with a Quebec Indian who encouraged them to drink a tea made from pine bark and needles. While OPCs found in this extract are mostly known for their antioxidant-producing benefits, these amazing compounds exude antibacterial, antiviral, anticarcinogenic, anti-aging, anti-inflammatory and anti-allergic properties. whole-body health. Four hundred years later, a French researcher named Jacques Masquelier did some studies to understand why this natural remedy was so effective. (3), Ototoxicity is ear poisoning and can occur when exposed to certain drugs or chemicals, such as cisplatin, that damage the inner ear or the vestibulocochlear nerve. 2005 - 2023 WebMD LLC. In 19 smokers, increased platelet aggregation was more significantly reduced by 200 mg than either 10 mg or 100 mg of Pycnogenol. We do not aim to diagnose, treat, cure or prevent any illness or disease. According to a large analysis, Pycnogenol may reduce osteoarthritis symptoms and pain short-term [45, 46]. For people who have symptoms that are more severe, traditional medicine is probably more effective. Thirty patients were treated with 150 mg of Pycnogenol a day and the other 10 patients with placebo for a period of two months. Pycnogenol has given indications that it might be able to benefit heart and artery health, to include reducing high blood pressure. Enzogenol also may reduce mental fatigue and sleep problems [82]. She loves communicating science and empowering people to achieve their optimal health.